A recent systematic review and network meta-analysis in The Lancet has shown that anti-depressants are an effective treatment for moderate to major depression. The study looked at data from 522 trials, with 116,477 participants and found that all antidepressants were more effective than placebo in adults with major depressive disorder. Some antidepressants were more efficacious with a higher response rate than others, and some antidepressants were better tolerated by participants than others. This review may help clinicians help patients with choice or dose of antidepressants, and help compliance and concordance with treatment.

Cipriani A, Furukawa T, Salanti G, et al. (2018) Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: A systematic review and network meta-analysis. The Lancet 391(10128): 1357–1366. DOI: 10.1016/S0140-6736(17)32802-7.

Conclusion: Antidepressants are more effective than placebo for patients who suffer from moderate to major depression.
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